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on the Renin-angiotensin-aldosterone system, hypotension can also occur in hypertensive patients with hypovolemia, such as a diuretic treatment in high doses. The initiation of the treatment will be cautious in attempting to correct hypovolemia.
-In heart failure, hypotension, is one of the adverse events most frequently observed with impairment of renal function and hyperkalemia. Arterial hypotensions frequency increases with age, diabetes or association with another treatment acting on the Renin-angiotensin-aldosterone system and in some cases may require a reduction in the dose or discontinuation of treatment (see also, "follow-up of patients with heart failure" in paragraph hyperkalemia, and dosage and administration, interactions and adverse reactions sections).
RENOVASCULAIRE arterial HYPERTENSION: there is an increased risk of severe hypotension and renal failure when patients with bilateral renal artery stenosis or renal artery stenosis on unique functional kidney, receive drugs acting on the Renin-angiotensin-aldosterone system. A similar phenomenon is expected with the Angiotensin II receptor antagonists.
RENAL AND TRANSPLANT RENAL FAILURE:
-Patients treated by ATACAND, as with other drugs acting on the Renin-angiotensin-aldosterone system, impairment of renal function may occur in patients with risk factors.
. When ATACAND is used in the hypertensive with impairment of renal function, a periodic review of potassium and serum creatinine is recommended.
. in heart failure, impairment of renal function is one of the adverse events most frequently observed with arterial hypotension and hyperkalemia. Its frequency increases with age, diabetes or association with another drug acting on the Renin-angiotensin-aldosterone system and can in some cases require a dose reduction or discontinuation of treatment (see also, "follow-up of patients with heart failure" in paragraph hyperkalemia, and dosage and administration, interactions and adverse reactions sections).
-No experience is available for the use of ATACAND in patients having had a recent kidney transplant.
HEMODIALYSIS: in dialysis patients, blood pressure can be especially sensitive to the blocking AT1 receptors, hypovolemia and activation of the Renin-angiotensin-aldosterone system. Accordingly, the dose of ATACAND should be increased gradually in these patients with blood pressure monitoring.
HYPERKALIEMIE:
-In the hypertensive patient during treatment with other drugs acting on the Renin-angiotensin-aldosterone system, hyperkalemia can occur, especially in the presence of renal failure or heart failure. A review of the performed in these patients at risk is recommended (see interactions).
-In heart failure, hyperkalemia is one of the adverse events most frequently observed with impairment of renal function and blood pressure hypotension. The hyperkaliémies frequency increases with age, diabetes or association with another drug acting on the Renin-angiotensin-aldosterone system and may in some cases require a dose reduction or discontinuation of treatment (see also Posology and method of administration, interactions and adverse reactions).

Atacand is an antagonist of vasoconstrictor angiotensin II. The drug relaxes and widens blood vessels to treat hypertension.

Atacand is in a group of drugs called angiotensin II receptor antagonists. It keeps blood vessels from narrowing, which lowers blood pressure and improves blood flow.